Differin 0.1% Cream 30g

£39.00

Differin Cream is a prescription acne treatment containing adapalene, a retinoid that unclogs pores, reduces inflammation, and helps prevent future breakouts. Suitable for dry or sensitive skin. Packaging and branding may vary.

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Differin 0.1% Cream (30g) is a clinically proven topical acne treatment containing adapalene, a third-generation retinoid. It is designed to treat mild to moderate acne, including blackheads, whiteheads, papules, and pustules.

This cream formulation is particularly suitable for individuals with dry or sensitive skin, offering the same effective acne treatment as the gel but with a more hydrating, less irritating base. Suitable for adults and adolescents aged 12 years and over, it supports clearer, smoother, and healthier-looking skin with consistent use.


How It Works

Differin Cream contains adapalene 0.1%, which works by normalising skin cell turnover and preventing pores from becoming blocked — a key cause of acne.

It also helps reduce inflammation, easing redness and swelling associated with breakouts. Adapalene is stable in light and oxygen, ensuring reliable performance and improved tolerability compared to older retinoids.


Key Benefits of Differin Cream 30g (Ideal for Dry Skin)

  • Treats multiple types of acne (blackheads, whiteheads, inflamed spots)

  • Cream-based formula helps support skin hydration

  • Better suited for dry or sensitive skin compared to gel formulations

  • Helps reduce redness and inflammation

  • Prevents new breakouts from forming

  • Non-comedogenic (won’t clog pores)

  • Fragrance-free and gentle on skin

  • 30g size ideal for consistent, long-term treatment


Why Choose the Cream Over the Gel?

The cream version of Differin is often preferred by those who experience dryness or irritation with acne treatments. Its emollient base helps to reduce the likelihood of excessive dryness while still delivering effective acne control.

This makes it a good option for patients with drier skin types or those new to retinoid treatments.


Important Information

  • Apply once daily in the evening unless directed otherwise by a healthcare professional

  • Mild dryness, redness, or irritation may occur initially as your skin adjusts

  • Use a moisturiser and daily sunscreen (SPF 30+) to protect sensitive skin

  • Avoid use on broken, sunburnt, or eczematous skin

  • Do not combine with other retinoids or harsh exfoliants unless advised

  • If irritation persists, reduce frequency or seek medical advice


⚠️ Note: While the cream is more suitable for dry skin, adapalene can still cause dryness or irritation, especially during the first few weeks of use. Supporting your routine with a gentle cleanser and moisturiser is recommended.

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

  • Apply a thin layer once daily in the evening to clean, dry skin

  • Use fingertips to spread evenly over affected areas

  • Avoid contact with eyes, lips, and broken skin

  • Use moisturiser as needed to manage dryness

  • Always use sunscreen during the day

  • Store below 25°C

  • Keep in original packaging

  • Keep out of reach of children

Ingredients

Active Ingredient:

  • Adapalene 0.1% w/w

Other Ingredients:

  • Carbomer

  • Propylene glycol

  • Poloxamer 182

  • Sodium hydroxide

  • Methyl parahydroxybenzoate

  • Phenoxyethanol

  • Water

Side Effects

Common side effects may include:

  • Dryness or peeling

  • Skin irritation

  • Redness

  • Mild stinging or burning

Serious (rare) side effects:

  • Severe skin irritation or blistering

  • Allergic reaction (rash, itching, swelling)

  • Photosensitivity reactions

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not use Differin Gel if allergic to adapalene or any listed ingredients. Avoid use on broken, sunburnt, or eczematous skin. Use with caution during pregnancy or breastfeeding—only if prescribed. Avoid excessive sun exposure and use a broad-spectrum SPF daily. Do not combine with other retinoids or harsh topical products unless advised by your doctor.

  • Differin treats acne by unclogging pores, reducing inflammation, and preventing new spots from forming.
  • Differin usually takes 6 to 8 weeks to show visible results, but some people may notice improvements sooner.
  • Yes, using a moisturiser alongside Differin helps reduce dryness and keeps your skin barrier healthy.
  • Yes, Differin can cause a short-term purge as it speeds up skin turnover. This should settle after a few weeks.
  • No, Differin is a prescription-only acne treatment in the UK and should be used under medical supervision.